P048 Decreased SHIP1 activity in Crohn's disease
نویسندگان
چکیده
منابع مشابه
Analysis of SHIP1 expression and activity in Crohn’s disease patients
BACKGROUND SH2 domain containing inositol-5-phosphatase (SHIP1) is an important modulator of innate and adaptive immunity. In mice, loss of SHIP1 provokes severe ileitis resembling Crohn's disease (CD), as a result of deregulated immune responses, altered cytokine production and intestinal fibrosis. Recently, SHIP1 activity was shown to be correlated to the presence of a CD-associated single nu...
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We here report a case of a young man who presented to his general practitioner with diarrhea. Inflammatory bowel disease was suspected and a colonoscopy showed aphthous lesions suggestive of Crohns' disease but biopsies revealed eggs of Enterobius vermicularis. When treated for this parasite, his symptoms were alleviated and a followup colonoscopy revealed a normal colon and distal ileum. Enter...
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Purpose: MR enterography (MRE) is one of the mainstays in the evaluation of Crohns disease (CD). A wide variety of studies have attempted to improve the sensitivity and specificity of MRE, all focusing on the evaluation of static images [1]. MRE however allows not only the static display of morphology, but can be combined with ultrafast scanning techniques (cineMRE) for analysis of bowel motili...
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Derek Jewell Professor of Gastroenterology, Gastroenterology Unit, Radcliffe Infirmary, Oxford, OX2 6HE, UK. Tel: +44 (0) 1865 224829; Fax: +44 (0) 1865 790792; E-mail: [email protected] The genetics of inflammatory bowel disease (IBD) is an area of enormous topical interest. Crohn’s disease is one of the first polygenic diseases in which a susceptibility gene (NOD2 ) ...
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ژورنال
عنوان ژورنال: Journal of Crohn's and Colitis
سال: 2012
ISSN: 1873-9946
DOI: 10.1016/s1873-9946(12)60069-5